Extracellular matrix protein 1 inhibits the activity of matrix metalloproteinase 9 through high-affinity protein/protein interactions.

@article{Fujimoto2006ExtracellularMP,
  title={Extracellular matrix protein 1 inhibits the activity of matrix metalloproteinase 9 through high-affinity protein/protein interactions.},
  author={Norihiro Fujimoto and Joseph P Terlizzi and Sirpa A. Aho and Raymond J Brittingham and Andrzej Fertala and Noritaka Oyama and J A McGrath and Jouni Uitto},
  journal={Experimental dermatology},
  year={2006},
  volume={15 4},
  pages={300-7}
}
Extracellular matrix protein 1 (ECM1), an approximately 85-kDa glycoprotein with broad tissue distribution, harbors mutations in lipoid proteinosis (LP), a heritable disease characterized by reduplication of basement membranes and hyalinization of dermis, associated with neurologic disorders. The mechanisms leading from ECM1 mutations to LP phenotype are unknown. In this study, we explored ECM1 protein-protein interactions utilizing yeast two-hybrid genetic screen of human placental library… CONTINUE READING

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