Extracellular matrix of glioblastoma inhibits polarization and transmigration of T cells: the role of tenascin-C in immune suppression.

@article{Huang2010ExtracellularMO,
  title={Extracellular matrix of glioblastoma inhibits polarization and transmigration of T cells: the role of tenascin-C in immune suppression.},
  author={Jyun-Yuan Huang and Yu-Jung Cheng and Yu-ping Lin and Huan-Ching Lin and Chung-Chen Su and Rudy Juliano and Bei-chang Yang},
  journal={Journal of immunology},
  year={2010},
  volume={185 3},
  pages={1450-9}
}
Dense accumulations of T cells are often found in peritumoral areas, which reduce the efficiency of contact-dependent lysis of tumor cells. We demonstrate in this study that the extracellular matrix (ECM) produced by tumors can directly regulate T cell migration. The transmigration rate of several T cells including peripheral blood primary T cell, Jurkat, and Molt-4 measured for glioma cells or glioma ECM was consistently low. Jurkat cells showed reduced amoeba-like shape formation and delayed… CONTINUE READING