Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis.

@article{Godoy2009ExtracellularMM,
  title={Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis.},
  author={Patricio Godoy and Jan G. Hengstler and Iryna Ilkavets and Christoph Meyer and Anastasia Bachmann and Alexandra M Mueller and Gregor Tuschl and Stefan M{\"u}ller and Steven Dooley},
  journal={Hepatology},
  year={2009},
  volume={49 6},
  pages={2031-43}
}
UNLABELLED Hepatocytes in culture are a valuable tool to investigate mechanisms involved in the response of the liver to cytokines. However, it is well established that hepatocytes cultured on monolayers of dried stiff collagen dedifferentiate, losing specialized liver functions. In this study, we show that hepatocyte dedifferentiation is a reversible consequence of a specific signaling network constellation triggered by the extracellular matrix. A dried stiff collagen activates focal adhesion… CONTINUE READING
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The role of matrix stiffness in regulating cell behavior

  • RG Wells
  • 2008

The role of matrix stiffness in regulating cell behavior. HEPATOLOGY 2008;47:1394-1400

  • RG Wells
  • 2008

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