Extracellular matrix interacts with soluble CD95L: Retention and enhancement of cytotoxicity

@article{Aoki2001ExtracellularMI,
  title={Extracellular matrix interacts with soluble CD95L: Retention and enhancement of cytotoxicity},
  author={Kazunori Aoki and Masayuki Kurooka and Jian-Jun Chen and Jerzy Petryniak and Elizabeth G. Nabel and Gary J. Nabel},
  journal={Nature Immunology},
  year={2001},
  volume={2},
  pages={333-337}
}
Fas ligand (CD95L) is synthesized both on the cell surface membrane and in a soluble form. Although CD95L contributes to immune privilege in the cornea and testis, the functions of these alternatively processed proteins are not well understood. Some reports suggest that the cytotoxicity of soluble CD95L is insignificant, whereas others show potent responses in vivo, including hepatocyte apoptosis that causes liver failure. We show here that extracellular matrix proteins interact with soluble… CONTINUE READING