Extracellular matrix in renal cell carcinomas.

  title={Extracellular matrix in renal cell carcinomas.},
  author={Jouko Lohi and Ilmo Leivo and J Oivula and V. P. Lehto and Ismo Virtanen},
  journal={Histology and histopathology},
  volume={13 3},
Extracellular matrix (ECM) may be divided into interstitial matrix and the basement membrane (BM). ECM influences a variety of epithelial cell behaviours, including proliferation, differentiation, and morphogenesis, maybe most widely studied in kidney morphogenesis. In carcinomas, including renal cell carcinomas (RCCs), these properties and interactions of cells with interstitial matrix and BM are disturbed. As a carcinoma with a tendency to spread to distant sites, RCC is an interesting target… CONTINUE READING
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