Extracellular matrix deposition by primary human lung fibroblasts in response to TGF-β1 and TGF-β3.

@article{Eickelberg1999ExtracellularMD,
  title={Extracellular matrix deposition by primary human lung fibroblasts in response to TGF-β1 and TGF-β3.},
  author={Oliver Eickelberg and Eleonore K{\"o}hler and Frank Reichenberger and Sybille Bertschin and Thomas Woodtli and P. Erne and Andr{\'e} Paul Perruchoud and Michael Roth},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={1999},
  volume={276 5},
  pages={L814-L824}
}
Increased collagen and extracellular matrix (ECM) deposition within the lung is a characteristic feature of lung fibrosis. Transforming growth factor (TGF)-β isoforms play a pivotal role in the production of collagen and ECM. In this study, we investigated the effects of TGF-β1 and TGF-β3 on the main processes controlling ECM deposition using primary human lung fibroblasts. We analyzed 1) collagen metabolism by [3H]proline incorporation, 2) matrix metalloproteinase (MMP) expression by substrate… CONTINUE READING
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