Extracellular matrix and perineuronal nets in CNS repair.

  title={Extracellular matrix and perineuronal nets in CNS repair.},
  author={Jessica C F Kwok and Gunnar Dick and Difei Wang and James W. Fawcett},
  journal={Developmental neurobiology},
  volume={71 11},
A perineuronal net (PNN) is a layer of lattice-like matrix which enwraps the surface of the soma and dendrites, and in some cases the axon initial segments, in sub-populations of neurons in the central nervous system (CNS). First reported by Camillo Golgi more than a century ago, the molecular structure and the potential role of this matrix have only been unraveled in the last few decades. PNNs are mainly composed of hyaluronan, chondroitin sulfate proteoglycans, link proteins, and tenascin R… CONTINUE READING