Extracellular matrix and HIF-1 signaling: the role of prolidase.

@article{Surayski2008ExtracellularMA,
  title={Extracellular matrix and HIF-1 signaling: the role of prolidase.},
  author={Arkadiusz Surażyński and Steven P. Donald and Sandra K Cooper and Martin A Whiteside and Konstantin V Salnikow and Yongmin Liu and James Ming Phang},
  journal={International journal of cancer},
  year={2008},
  volume={122 6},
  pages={1435-40}
}
Hypoxia-inducible factor-1 (HIF-1) plays an important role in stress-responsive gene expression. Although primarily sensitive to hypoxia, HIF-1 signaling can be regulated by a number of stress factors including metabolic stress, growth factors and molecules present in the extracellular matrix (ECM). Degradation of ECM by metalloproteinases (MMP) is important for tumor progression, invasion and metastasis. ECM is predominantly collagen, and the imino acids (Pro and HyPro) comprise 25% of… CONTINUE READING
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