Extracellular matrix affects different aspects of cell behaviour potentially involved in response to aminolevulinic acid-based photoinactivation.

@article{underlkov2018ExtracellularMA,
  title={Extracellular matrix affects different aspects of cell behaviour potentially involved in response to aminolevulinic acid-based photoinactivation.},
  author={Beata {\vC}underl{\'i}kov{\'a} and Barbora Fiľov{\'a} and Karol Kajo and Miroslava Vallov{\'a} and Zuzana Bal{\'a}zsiov{\'a} and Michal Trnka and Anton Mate{\'a}{\vs}ik},
  journal={Journal of photochemistry and photobiology. B, Biology},
  year={2018},
  volume={189},
  pages={
          283-291
        }
}
Two-dimensional cell cultures do not seem to be reliable models for anticancer drug discovery and validation. Numerous in vitro tumour models of different complexity have been evaluated with the aim to enhance anticancer drug development, but whether all these models could be considered as physiologically relevant is a question. Even type of the extracellular matrix may markedly influence experimental results and supposedly also clinical treatment outcome. By using three human oesophageal cell… CONTINUE READING