Extracellular matrix: A dynamic microenvironment for stem cell niche☆

  title={Extracellular matrix: A dynamic microenvironment for stem cell niche☆},
  author={Francesca Gattazzo and Anna Urciuolo and Paolo Bonaldo},
  booktitle={Biochimica et biophysica acta},
BACKGROUND Extracellular matrix (ECM) is a dynamic and complex environment characterized by biophysical, mechanical and biochemical properties specific for each tissue and able to regulate cell behavior. Stem cells have a key role in the maintenance and regeneration of tissues and they are located in a specific microenvironment, defined as niche. SCOPE OF REVIEW We overview the progresses that have been made in elucidating stem cell niches and discuss the mechanisms by which ECM affects stem… CONTINUE READING
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