Extracellular matrix, integrins, and growth factors as tailors of the stem cell niche.

@article{Brizzi2012ExtracellularMI,
  title={Extracellular matrix, integrins, and growth factors as tailors of the stem cell niche.},
  author={Maria Felice Brizzi and Guido Tarone and Paola Defilippi},
  journal={Current opinion in cell biology},
  year={2012},
  volume={24 5},
  pages={645-51}
}
It is widely acknowledged that integrins, the major receptors for the extracellular matrix (ECM) proteins, exert an extensive crosstalk with many growth factor and cytokine receptors. Among them, growth factor receptors, such as the EGFR, MET, PDGFR and VEGFR, and the IL-3 receptor have been shown to be physically and functionally associated to integrins… CONTINUE READING