Extracellular magnesium and calcium reduce myotonia in ClC-1 inhibited rat muscle.

  title={Extracellular magnesium and calcium reduce myotonia in ClC-1 inhibited rat muscle.},
  author={Martin Skov and Anders Riisager and James A Fraser and Ole B{\ae}kgaard Nielsen and Thomas Holm Pedersen},
  journal={Neuromuscular disorders : NMD},
  volume={23 6},
Loss-of-function mutations in the ClC-1 Cl(-) channel trigger skeletal muscle hyperexcitability in myotonia congenita. For reasons that remain unclear, the severity of the myotonic symptoms can vary markedly even among patients with identical ClC-1 mutations, and may become exacerbated during pregnancy and with diuretic treatment. Since both these conditions are associated with hypomagnesemia and hypocalcemia, we explored whether extracellular Mg(2+) and Ca(2+) ([Mg(2+)]o and [Ca(2+)]o) can… CONTINUE READING

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