Extracellular lysines on the plasmodial surface anion channel involved in Na+ exclusion.

@article{Cohn2003ExtracellularLO,
  title={Extracellular lysines on the plasmodial surface anion channel involved in Na+ exclusion.},
  author={Jamieson V Cohn and Abdulnaser Alkhalil and Marissa A Wagner and Thavamani Rajapandi and Sanjay A Desai},
  journal={Molecular and biochemical parasitology},
  year={2003},
  volume={132 1},
  pages={
          27-34
        }
}
The human malaria parasite, Plasmodium falciparum, induces an unusual ion channel, the plasmodial surface anion channel (PSAC), on its host red blood cell (RBC) membrane. PSAC has a broad selectivity with permeability to anions, sugars, amino acids, purines, and certain vitamins, suggesting a role in nutrient acquisition by the intracellular parasite. Permeating solutes cover a range of molecular sizes and may be either neutral or carry a net negative or positive charge. Despite this broad… CONTINUE READING
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