Extracellular levels of lactate, but not oxygen, reflect sleep homeostasis in the rat cerebral cortex.

@article{Dash2012ExtracellularLO,
  title={Extracellular levels of lactate, but not oxygen, reflect sleep homeostasis in the rat cerebral cortex.},
  author={Michael B Dash and Giulio Tononi and Chiara Cirelli},
  journal={Sleep},
  year={2012},
  volume={35 7},
  pages={909-19}
}
STUDY OBJECTIVE It is well established that brain metabolism is higher during wake and rapid eye movement (REM) sleep than in nonrapid eye movement (NREM) sleep. Most of the brain's energy is used to maintain neuronal firing and glutamatergic transmission. Recent evidence shows that cortical firing rates, extracellular glutamate levels, and markers of excitatory synaptic strength increase with time spent awake and decline throughout NREM sleep. These data imply that the metabolic cost of each… CONTINUE READING

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