Extracellular lactate/pyruvate and glutamate changes in patients during per-operative episodes of cerebral ischaemia.

@article{KettWhite2002ExtracellularLA,
  title={Extracellular lactate/pyruvate and glutamate changes in patients during per-operative episodes of cerebral ischaemia.},
  author={Rupert Kett-White and Peter J. A. Hutchinson and Pippa G. Al-Rawi and Arun Kumar Gupta and Mark T O'Connell and John D. Pickard and Peter John Kirkpatrick},
  journal={Acta neurochirurgica. Supplement},
  year={2002},
  volume={81},
  pages={363-5}
}
OBJECTIVE Temporary Internal Carotid Artery (ICA) clipping necessary during aneurysm surgery was used as a model to investigate metabolic changes in the human brain during defined episodes of ischaemia. DESIGN An observational study using intracerebral monitors: PBO2 (Neurotrend) and microdialysis (CMA, Sweden). SUBJECTS 16 patients monitored during complex aneurysm surgery. OUTCOME MEASURES Changes in extracellular concentrations of glucose, lactate, and glutamate and lactate/pyruvate… CONTINUE READING