Extracellular inosine modulates ERK 1/2 and p38 phosphorylation in cultured Sertoli cells: possible participation in TNF-alpha modulation of ERK 1/2.

@article{Souza2005ExtracellularIM,
  title={Extracellular inosine modulates ERK 1/2 and p38 phosphorylation in cultured Sertoli cells: possible participation in TNF-alpha modulation of ERK 1/2.},
  author={Luiz Souza and Ana Paula Horn and Daniel Pens Gelain and Fernanda Rafaela Jardim and Guido Lenz and Elena Aida Bernard},
  journal={Life sciences},
  year={2005},
  volume={77 24},
  pages={3117-26}
}
Extracellular ATP and adenosine modulation of MAPKs is well described in different cells types, but few studies have addressed the effects of extracellular inosine on these kinases. Previous results showed that hydrogen peroxide and TNF-alpha increase extracellular inosine concentration in cultured Sertoli cells and this nucleoside protects Sertoli cells… CONTINUE READING