Extracellular histone release in response to traumatic injury: implications for a compensatory role of activated protein C.

@article{Kutcher2012ExtracellularHR,
  title={Extracellular histone release in response to traumatic injury: implications for a compensatory role of activated protein C.},
  author={Matthew E. Kutcher and Jun Xu and Ryan F. Vilardi and Coral Ho and Charles T. Esmon and Mitchell Jay Cohen},
  journal={The journal of trauma and acute care surgery},
  year={2012},
  volume={73 6},
  pages={1389-94}
}
BACKGROUND Tissue injury leads to the release of DAMPs (damage-associated molecular patterns) that may drive a sterile inflammatory response; however, the role of extracellular histone levels after traumatic injury remains unexplored. We hypothesized that extracellular histone levels would be increased and associated with poor outcomes after traumatic injury. METHODS In this prognostic study, plasma was prospectively collected from 132 critically injured trauma patients on arrival and 6 hours… CONTINUE READING
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