Extracellular histone H1 is neurotoxic and drives a pro-inflammatory response in microglia

Abstract

In neurodegenerative conditions and following brain trauma it is not understood why neurons die while astrocytes and microglia survive and adopt pro-inflammatory phenotypes. We show here that the damaged adult brain releases diffusible factors that can kill cortical neurons and we have identified histone H1 as a major extracellular candidate that causes… (More)
DOI: 10.12688/f1000research.2-148.v1

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