Extracellular heat shock protein 70 inhibits tumour necrosis factor-α induced proinflammatory mediator production in fibroblast-like synoviocytes

@article{Luo2008ExtracellularHS,
  title={Extracellular heat shock protein 70 inhibits tumour necrosis factor-α induced proinflammatory mediator production in fibroblast-like synoviocytes},
  author={Xinjing Luo and Xiaoxia Zuo and Yaou Zhou and Bing Zhang and Yongzhong Shi and Meidong Liu and Kangkai Wang and D Randy McMillian and Xian-Zhong Xiao},
  journal={Arthritis Research & Therapy},
  year={2008},
  volume={10},
  pages={R41 - R41}
}
INTRODUCTION It was recently suggested that heat shock protein (HSP)70, an intracellular protein, is a potential mediator of inflammatory disease when it is released into the extracellular compartment. Although elevated HSP70 levels have been identified in rheumatoid arthritis (RA) synovial tissues and RA synovial fluid compared with patients with osteoarthritis and healthy individuals, it remains unclear what role extracellular HSP70 plays in the pathogenesis of RA. This study was conducted to… CONTINUE READING

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