Extracellular guanosine regulates extracellular adenosine levels.

  title={Extracellular guanosine regulates extracellular adenosine levels.},
  author={Edwin K Jackson and Dongmei Cheng and Travis C. Jackson and Jonathan D. Verrier and Delbert G. Gillespie},
  journal={American journal of physiology. Cell physiology},
  volume={304 5},
The aim of this investigation was to test the hypothesis that extracellular guanosine regulates extracellular adenosine levels. Rat preglomerular vascular smooth muscle cells were incubated with adenosine, guanosine, or both. Guanosine (30 μmol/l) per se had little effect on extracellular adenosine levels. Extracellular adenosine levels 1 h after addition of adenosine (3 μmol/l) were 0.125 ± 0.020 μmol/l, indicating rapid disposition of extracellular adenosine. Extracellular adenosine levels 1… CONTINUE READING