Extracellular guanosine and GTP promote expression of differentiation markers and induce S-phase cell-cycle arrest in human SH-SY5Y neuroblastoma cells

@article{Guarnieri2009ExtracellularGA,
  title={Extracellular guanosine and GTP promote expression of differentiation markers and induce S-phase cell-cycle arrest in human SH-SY5Y neuroblastoma cells},
  author={Simone Guarnieri and Rachel Pilla and Caterina Morabito and Silvana Sacchetti and Maria A Mariggi{\`o}},
  journal={International Journal of Developmental Neuroscience},
  year={2009},
  volume={27},
  pages={135-147}
}
SH-SY5Y neuroblastoma cells, a model for studying neuronal differentiation, are able to differentiate into either cholinergic or dopaminergic/adrenergic phenotypes depending on media conditions. Using this system, we asked whether guanosine (Guo) or guanosine-5'-triphosphate (GTP) are able to drive differentiation towards one particular phenotype. Differentiation was determined by evaluating the frequency of cells bearing neurites and assessing neurite length after exposure to different… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 27 CITATIONS

Antiproliferation effect of guanosine on HCT 116 cells involves MAPK and AMPK pathways.

  • Nucleosides, nucleotides & nucleic acids
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

The Guanine-Based Purinergic System: The Tale of An Orphan Neuromodulation

  • Front. Pharmacol.
  • 2016
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Origin, utilization, and recycling of nucleosides in the central nervous system.

  • Advances in physiology education
  • 2011
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Nitrogenous Base Ribonucleoside Deoxyribonucleoside Adenine Adenosine Deoxyadenosine Guanine Guanosine Deoxyguanosine Hypoxanthine Inosine Deoxyinosine Thymine 5-Methyluridine Thymidine Uracil Uridine Deoxyuridine

Carly Morrison, Kalpanie Bandara, Wenge Wang, Lin Zhang, Bruno Figueroa
  • 2019
VIEW 2 EXCERPTS

Physiological Responses of Jurkat Lymphocytes to Simulated Microgravity Conditions

  • International journal of molecular sciences
  • 2019
VIEW 1 EXCERPT
CITES METHODS

References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

Similar Papers