Extracellular glutamate diffusion determines the occupancy of glutamate receptors at CA1 synapses in the hippocampus.

@article{Kullmann1999ExtracellularGD,
  title={Extracellular glutamate diffusion determines the occupancy of glutamate receptors at CA1 synapses in the hippocampus.},
  author={Dimitri Michael Kullmann and M Y Min and Fredrik Aszt{\'e}ly and Dmitri A. Rusakov},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={1999},
  volume={354 1381},
  pages={
          395-402
        }
}
Following exocytosis at excitatory synapses in the brain, glutamate binds to several subtypes of postsynaptic receptors. The degree of occupancy of AMPA and NMDA receptors at hippocampal synapses is, however, not known. One approach to estimate receptor occupancy is to examine quantal amplitude fluctuations of postsynaptic signals in hippocampal neurons studied in vitro. The results of such experiments suggest that NMDA receptors at CA1 synapses are activated not only by glutamate released from… CONTINUE READING
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