Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin.

@article{Koh2004ExtracellularFO,
  title={Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin.},
  author={Jeong Tae Koh and Hyun Kook and Hae Jin Kee and Young-Woo Seo and Byung Chul Jeong and Ji Hee Lee and Mi-young Kim and Kyung Chul Yoon and Shin Chul Jung and Kyung Keun Kim},
  journal={Experimental cell research},
  year={2004},
  volume={294 1},
  pages={172-84}
}
Brain-specific angiogenesis inhibitor 1 (BAI1) is a transmembrane protein with anti-angiogenic activity. The mechanisms underlying BAI1 activity are unknown. In this study, we found that overexpression of BAI1 increased cell death in human umbilical vein endothelial cells (HUVECs) and, to a lesser degree, in SHSY5Y and U343 cells. Conditioned medium from BAI1-transfected U343 cells inhibited proliferation of HUVECs, and this effect was neutralized by addition of anti-BAI1 serum. The conditioned… CONTINUE READING