Extracellular domains play different roles in gap junction formation and docking compatibility.

@article{Bai2014ExtracellularDP,
  title={Extracellular domains play different roles in gap junction formation and docking compatibility.},
  author={Donglin Bai and Ao Hong Wang},
  journal={The Biochemical journal},
  year={2014},
  volume={458 1},
  pages={1-10}
}
GJ (gap junction) channels mediate direct intercellular communication and play an important role in many physiological processes. Six connexins oligomerize to form a hemichannel and two hemichannels dock together end-to-end to form a GJ channel. Connexin extracellular domains (E1 and E2) have been shown to be important for the docking, but the molecular mechanisms behind the docking and formation of GJ channels are not clear. Recent developments in atomic GJ structure and functional studies on… CONTINUE READING

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