Extracellular disulfide exchange and the regulation of cellular function.

@article{Jordan2006ExtracellularDE,
  title={Extracellular disulfide exchange and the regulation of cellular function.},
  author={Peter A. Jordan and Jonathan M. Gibbins},
  journal={Antioxidants & redox signaling},
  year={2006},
  volume={8 3-4},
  pages={312-24}
}
An emerging concept is that disulfide bonds can act as a dynamic scaffold to present mature proteins in different conformational and functional states on the cell surface. Two examples are the conversion of the receptor, integrin alphaIIbbeta3, from a low affinity to a high affinity state, and the interaction of CD4 receptor with the HIV-1 envelope… CONTINUE READING