Extracellular diffusion is fast and isotropic in the stratum radiatum of hippocampal CA1 region in rat brain slices.

@article{Hrabetova2005ExtracellularDI,
  title={Extracellular diffusion is fast and isotropic in the stratum radiatum of hippocampal CA1 region in rat brain slices.},
  author={Sabina Hrabetova},
  journal={Hippocampus},
  year={2005},
  volume={15 4},
  pages={441-50}
}
Molecular transport in brain extracellular space (ECS) is hindered by the structure of the tissue. Diffusion analysis of small extracellular markers quantifies tissue hindrance, expressed as tortuosity lambda = (D/D*)(1/2), where D is the free diffusion coefficient and D* is the effective diffusion coefficient in tissue. In healthy brain, lambda is approximately 1.6, but the nature of this parameter is poorly understood. We report that the stratum radiatum of the hippocampal CA1 region in vitro… CONTINUE READING