Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice.

@article{Laferla1996ExtracellularDO,
  title={Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice.},
  author={Frank M. Laferla and Carol K. Hall and Lien Ngo and Gilbert Jay},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={98 7},
  pages={
          1626-32
        }
}
The finding that intracellular expression of the beta-amyloid protein (Abeta) under a neuron-specific promoter led progressively to degeneration and death of neurons in the brains of transgenic mice provides a unique opportunity to utilize this animal model to both understand the mechanism that underlies neuronal cell death and define the complexity of events which may ensue. We observed a correlation between Abeta accumulation in selective neurons and activation of p53, a protein that has been… CONTINUE READING

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