Extracellular concentrations of cocaine and dopamine are enhanced during chronic cocaine administration.

@article{Pettit1990ExtracellularCO,
  title={Extracellular concentrations of cocaine and dopamine are enhanced during chronic cocaine administration.},
  author={Hugh O. Pettit and H T Pan and Loren Howell Parsons and J. B. Justice},
  journal={Journal of neurochemistry},
  year={1990},
  volume={55 3},
  pages={798-804}
}
Chronic cocaine administration produces significant increases in cocaine-induced locomotor activity and stereotypy. In vivo microdialysis procedures were used to monitor extracellular dopamine (DA) and cocaine concentrations in the nucleus accumbens (N ACC) and cocaine concentrations in plasma of animals that received chronic or acute cocaine treatments. Following a cocaine challenge injection, concentrations of both cocaine and DA increased to significantly higher levels over time in animals… CONTINUE READING

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