Extracellular calcium sensing and signalling.

@article{Hofer2003ExtracellularCS,
  title={Extracellular calcium sensing and signalling.},
  author={Aldebaran M. Hofer and Edward Meigs Brown},
  journal={Nature reviews. Molecular cell biology},
  year={2003},
  volume={4 7},
  pages={530-8}
}
Ca2+ is well established as an intracellular second messenger. However, the molecular identification of a detector for extracellular Ca2+--the extracellular calcium-sensing receptor--has opened up the possibility that Ca2+ might also function as a messenger outside cells. Information about the local extracellular Ca2+ concentration is conveyed to the interior of many cell types through this unique G-protein-coupled receptor. Here, we describe new emerging concepts concerning the signalling… CONTINUE READING
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