Extracellular calcium participates in responses to acetylcholine in Xenopus oocytes.

@article{LupuMeiri1990ExtracellularCP,
  title={Extracellular calcium participates in responses to acetylcholine in Xenopus oocytes.},
  author={Monica Lupu-Meiri and Hagit Shapira and Y Oron},
  journal={FEBS letters},
  year={1990},
  volume={262 2},
  pages={165-9}
}
We tested the contribution of extracellular calcium (Ca2+) to membrane electrical responses to acetylcholine (ACh) in native Xenopus oocytes. Removal of Cao caused a decrease in both the rapid (D1) and the slow (D2) chloride currents that comprise the common depolarizing response to ACh in native oocyte. The effect of Ca2+o removal on the muscarinic response was mimicked by the addition of 1 mM Mn2+, an effective antagonist of calcium influx, though not by antagonists of voltage-sensitive… CONTINUE READING