Extracellular calcium‐dependent regulation of transmembrane calcium fluxes in murine keratinocytes

@article{Reiss1991ExtracellularCR,
  title={Extracellular calcium‐dependent regulation of transmembrane calcium fluxes in murine keratinocytes},
  author={Michael Reiss and Lindsey Lipsey and Z. L. Zhou},
  journal={Journal of Cellular Physiology},
  year={1991},
  volume={147}
}
Because the level of extracellular Ca2+ is an important stimulus for differentiation of epidermal cells in vitro, we characterized the extracellular Ca2+ ‐dependent transmembrane Ca2+ fluxes in BALB/MK mouse keratinocytes. Increasing levels of extracellular Ca2+ ranging from 0.07 to 1.87 mM, stimulated the rate of 45Ca2+ uptake into these cells 10‐ to 70‐fold and doubled the rate of 45Ca2+ efflux. The divalent cations, Ni2+ and Co2+, were able to block the influx of Ca2+, but dihydropyridines… 
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