Extracellular annexins and dynamin are important for sequential steps in myoblast fusion

@inproceedings{Leikina2013ExtracellularAA,
  title={Extracellular annexins and dynamin are important for sequential steps in myoblast fusion},
  author={Evgenia Leikina and Kamran Melikov and Sarmistha Sanyal and Santosh Kumar Verma and Bokkee Eun and Claudia M. Gebert and Karl Pfeifer and Vladimir A. Lizunov and Michael M. Kozlov and Leonid V. Chernomordik},
  booktitle={The Journal of cell biology},
  year={2013}
}
Myoblast fusion into multinucleated myotubes is a crucial step in skeletal muscle development and regeneration. Here, we accumulated murine myoblasts at the ready-to-fuse stage by blocking formation of early fusion intermediates with lysophosphatidylcholine. Lifting the block allowed us to explore a largely synchronized fusion. We found that initial merger of two cell membranes detected as lipid mixing involved extracellular annexins A1 and A5 acting in a functionally redundant manner… CONTINUE READING
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