Extracellular amastigotes of Trypanosoma cruzi are potent inducers of phagocytosis in mammalian cells

@inproceedings{Fernandes2013ExtracellularAO,
  title={Extracellular amastigotes of Trypanosoma cruzi are potent inducers of phagocytosis in mammalian cells},
  author={Maria Cec{\'i}lia Di Ciero Fernandes and Andrew R. Flannery and Norma W Andrews and Renato Arruda Mortara},
  booktitle={Cellular microbiology},
  year={2013}
}
The protozoan parasite Trypanosoma cruzi, the aetiological agent of Chagas' disease, has two infective life cycle stages, trypomastigotes and amastigotes. While trypomastigotes actively enter mammalian cells, highly infective extracellular amastigotes (type I T. cruzi) rely on actin-mediated uptake, which is generally inefficient in non-professional phagocytes. We found that extracellular amastigotes (EAs) of T. cruzi G strain (type I), but not Y strain (type II), were taken up 100-fold more… CONTINUE READING
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