Extracellular alpha 6 integrin cleavage by urokinase-type plasminogen activator in human prostate cancer.

@article{Demetriou2004ExtracellularA6,
  title={Extracellular alpha 6 integrin cleavage by urokinase-type plasminogen activator in human prostate cancer.},
  author={Manolis C. Demetriou and Michael E. Pennington and Raymond B. Nagle and Anne E Cress},
  journal={Experimental cell research},
  year={2004},
  volume={294 2},
  pages={
          550-8
        }
}
During human prostate cancer progression, the integrin alpha6beta1 (laminin receptor) is expressed on the cancer cell surface during invasion and in lymph node metastases. We previously identified a novel structural variant of the alpha6 integrin called alpha6p. This variant was produced on the cell surface and was missing the beta-barrel extracellular domain. Using several different concentrations of amiloride, aminobenzamidine and PAI-1 and the urokinase-type plasminogen activator (uPA… CONTINUE READING
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