Extracellular alkalinity exacerbates injury of cultured cortical neurons.

  title={Extracellular alkalinity exacerbates injury of cultured cortical neurons.},
  author={Rona G. Giffard and John H Weiss and Dennis W. Choi},
  volume={23 12},
BACKGROUND AND PURPOSE We have previously shown that extracellular acidity protects cultured fetal murine neocortical neurons from glutamate toxicity and combined oxygen-glucose deprivation injury, an action at least in part mediated by reduction in N-methyl-D-aspartate receptor activation. We now investigate the effect of extracellular alkalinity on both glutamate neurotoxicity and injury due to combined oxygen-glucose deprivation. METHODS The effects of extracellular alkalinity during… CONTINUE READING
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