Extracellular alkaline shifts in rat hippocampal slice are mediated by NMDA and non-NMDA receptors.

@article{Chen1992ExtracellularAS,
  title={Extracellular alkaline shifts in rat hippocampal slice are mediated by NMDA and non-NMDA receptors.},
  author={James T. T. Chen and Mitchell Chesler},
  journal={Journal of neurophysiology},
  year={1992},
  volume={68 1},
  pages={
          342-4
        }
}
1. The pharmacology of synaptically evoked extracellular alkaline shifts was studied in the CA1 area of rat hippocampal slices. 2. Stimulus-evoked alkalinizations were unaffected by 2-amino-5-phosphonovalerate (APV) (20 microM). 3. 6-Cyano-7-nitro-nitroquinoxaline-2,3-dione (CNQX) (10 microM) inhibited the alkalinizations. In the continued presence of CNQX, an APV-sensitive, picrotoxin-insensitive, alkaline shift was elicited in low Mg2+ media. 4. Antidromic stimulation produced small alkaline… CONTINUE READING

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