Extracellular adenosine triphosphate increases cation permeability of chronic lymphocytic leukemic lymphocytes.

@article{Wiley1989ExtracellularAT,
  title={Extracellular adenosine triphosphate increases cation permeability of chronic lymphocytic leukemic lymphocytes.},
  author={James S. Wiley and George R Dubyak},
  journal={Blood},
  year={1989},
  volume={73 5},
  pages={1316-23}
}
Extracellular adenosine triphosphate (ATP) is known to reversibly increase the cation permeability of a variety of freshly isolated and cultured cell types. In this study the effects of extracellular ATP were studied using peripheral blood lymphocytes (PBL) isolated from both normal subjects and from patients with chronic lymphocytic leukemia (CLL). Changes in the permeability to Na+, Rb+, and Li+ ions were measured using conventional isotope and flame photometry techniques. In addition… CONTINUE READING