Extracellular addition of a domain of HIV-1 Vpr containing the amino acid sequence motif H(S/F)RIG causes cell membrane permeabilization and death.

@article{Macreadie1996ExtracellularAO,
  title={Extracellular addition of a domain of HIV-1 Vpr containing the amino acid sequence motif H(S/F)RIG causes cell membrane permeabilization and death.},
  author={Ian G Macreadie and C K Arunagiri and Dean R. Hewish and Jim F. White and Ahmed A. Azad},
  journal={Molecular microbiology},
  year={1996},
  volume={19 6},
  pages={1185-92}
}
Vpr is a virion-associated protein of human immunodeficiency virus type 1 (HIV-1) whose function in acquired immune deficiency syndrome (AIDS) has been uncertain. We previously employed yeast as a model to examine the effects of Vpr on basic cellular functions; intracellular Vpr was shown to cause cell-growth arrest and structural defects, and these effects were caused by a region of Vpr containing the sequence HFRIGCRHSRIG. Here we show that peptides containing the H(S/F)RIG amino acid… CONTINUE READING
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