Extracellular activities of human granzyme A. Monocyte activation by granzyme A versus alpha-thrombin.

@article{Sower1996ExtracellularAO,
  title={Extracellular activities of human granzyme A. Monocyte activation by granzyme A versus alpha-thrombin.},
  author={Laurie E. Sower and Christopher J. Froelich and N J Allegretto and Prof. Dr. M. M. Ros{\'e} and W D Hanna and Gary R. Klimpel},
  journal={Journal of immunology},
  year={1996},
  volume={156 7},
  pages={2585-90}
}
Granzymes, serine proteases located in the granules of cytotoxic T cel ls and NK cells, are essential for induction of target cell apoptosis. However, since cytotoxic cells constitutively secrete a portion of their synthesized granzymes, these proteases could mediate extracellular functions independent of their role in the lytic event. Thrombin, another serine protease, can induce cytokine production in a number of different cell types. In this study, we test the hypothesis that granzymes, like… CONTINUE READING