Extracellular acidosis is a novel danger signal alerting innate immunity via the NLRP3 inflammasome.

  title={Extracellular acidosis is a novel danger signal alerting innate immunity via the NLRP3 inflammasome.},
  author={Kristiina Rajam{\"a}ki and Tommy Nordstr{\"o}m and Katariina Nurmi and Karl E {\AA}kerman and Petri T. Kovanen and Katariina {\"O}{\"o}rni and Kari K Eklund},
  journal={The Journal of biological chemistry},
  volume={288 19},
BACKGROUND Local acidosis has been demonstrated in ischemic tissues and at inflammatory sites. RESULTS Acidic extracellular pH triggers NLRP3 inflammasome activation and interleukin-1β secretion in human macrophages. CONCLUSION Acidic pH represents a novel danger signal alerting the innate immunity. SIGNIFICANCE Local acidosis may promote inflammation at ischemic and inflammatory sites. Local extracellular acidification has been demonstrated at sites of ischemia and inflammation. IL-1β is… CONTINUE READING
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