Extracellular acidification enhances osteoclast survival through an NFAT-independent, protein kinase C-dependent pathway.

@article{Pereverzev2008ExtracellularAE,
  title={Extracellular acidification enhances osteoclast survival through an NFAT-independent, protein kinase C-dependent pathway.},
  author={Alexey Pereverzev and Svetlana V. Komarova and Jasminka Korcok and Souzan Armstrong and Gilles B Tremblay and S. Jeffrey Dixon and Stephen Michael Sims},
  journal={Bone},
  year={2008},
  volume={42 1},
  pages={150-61}
}
Systemic acidosis has detrimental effects on the skeleton and local acidosis is associated with bone destruction in inflammatory and neoplastic diseases. However, the mechanisms by which acidosis enhances osteoclastic bone resorption are poorly understood. Our aim was to examine the effects of acid on osteoclast survival and the involvement of cytosolic Ca(2+) in mediating these effects. Osteoclasts were isolated from long bones of newborn rats, and multinucleated osteoclast-like cells were… CONTINUE READING
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