Extracellular acidic pH modulates oxygen-dependent cytotoxic responses mediated by polymorphonuclear leucocytes and monocytes.

@article{Geffner1993ExtracellularAP,
  title={Extracellular acidic pH modulates oxygen-dependent cytotoxic responses mediated by polymorphonuclear leucocytes and monocytes.},
  author={Jorge Ra{\'u}l Geffner and Anal{\'i}a S Trevani and F S Minnucci and Marina Sandra Palermo and Norma Maugeri and Mart{\'i}n Amadeo Isturiz},
  journal={Clinical and experimental immunology},
  year={1993},
  volume={91 1},
  pages={164-9}
}
In the present study, we compared the ability of human neutrophils and monocytes to display oxygen-dependent cytotoxic responses at pH 7.4 and 6.2. Our results show that cytotoxicity induced by immune complexes (IC), zymosan, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and concanavalin A (Con A) were markedly increased when they were carried out at pH 6.2 instead of pH 7.4. Cytotoxicity induced by phorbol myristate acetate (PMA), on the contrary, was significantly decreased at pH 6.2. It is… CONTINUE READING