Extracellular accumulation of potently microbicidal bactericidal/permeability-increasing protein and p15s in an evolving sterile rabbit peritoneal inflammatory exudate.

@article{Weinrauch1995ExtracellularAO,
  title={Extracellular accumulation of potently microbicidal bactericidal/permeability-increasing protein and p15s in an evolving sterile rabbit peritoneal inflammatory exudate.},
  author={Yvette Weinrauch and Andrew Foreman and Chang Shu and Kol A. Zarember and Orlie Levy and Peter Elsbach and Jean Weiss},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={95 4},
  pages={1916-24}
}
To what extent the host defense role of granule-associated antibacterial proteins and peptides of PMN includes extracellular action has not been established. To address this question, we have analyzed the antibacterial activity of cell-free (ascitic) fluid (AF) obtained from glycogen-induced sterile inflammatory rabbit peritoneal exudates in which > 95% of the accumulating cells are PMN. AF, but not plasma collected in parallel, exhibits potent activity toward serum-resistant Gram-negative and… CONTINUE READING

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