Extracellular Zinc Competitively Inhibits Manganese Uptake and Compromises Oxidative Stress Management in Streptococcus pneumoniae

@inproceedings{Eijkelkamp2014ExtracellularZC,
  title={Extracellular Zinc Competitively Inhibits Manganese Uptake and Compromises Oxidative Stress Management in Streptococcus pneumoniae},
  author={Bart A Eijkelkamp and Jacqueline R. Morey and Miranda Ween and Cheryl-Lynn Y Ong and Alastair G McEwan and James C. Paton and Christopher A McDevitt},
  booktitle={PloS one},
  year={2014}
}
Streptococcus pneumoniae requires manganese for colonization of the human host, but the underlying molecular basis for this requirement has not been elucidated. Recently, it was shown that zinc could compromise manganese uptake and that zinc levels increased during infection by S. pneumoniae in all the niches that it colonized. Here we show, by quantitative means, that extracellular zinc acts in a dose dependent manner to competitively inhibit manganese uptake by S. pneumoniae, with an EC50 of… CONTINUE READING

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