Extracellular Vesicles Induce Mesenchymal Transition and Therapeutic Resistance in Glioblastomas through NF‐κB/STAT3 Signaling

@article{Schweiger2020ExtracellularVI,
  title={Extracellular Vesicles Induce Mesenchymal Transition and Therapeutic Resistance in Glioblastomas through NF‐$\kappa$B/STAT3 Signaling},
  author={M. Schweiger and Mao Li and Alberta Giovanazzi and Renata L Fleming and Elie I Tabet and I. Nakano and T. W{\"u}rdinger and E. Chiocca and Tian Tian and B. Tannous},
  journal={Advanced Biosystems},
  year={2020},
  volume={4}
}
Glioblastoma (GBM) is the most common primary malignant brain tumor and despite optimal treatment, long‐term survival remains uncommon. GBM can be roughly divided into three different molecular subtypes, each varying in aggressiveness and treatment resistance. Recent evidence shows plasticity between these subtypes in which the proneural (PN) glioma stem‐like cells (GSCs) undergo transition into the more aggressive mesenchymal (MES) subtype, leading to therapeutic resistance. Extracellular… Expand
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