Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation

@inproceedings{Ridder2014ExtracellularVT,
  title={Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation},
  author={Kirsten Ridder and Sascha Keller and Maria Dams and Anne-kathleen Rupp and Jessica Schlaudraff and Domenico Del Turco and Julia Starmann and Jadranka Macas and Darja Karpova and Kavi Devraj and Candan Depboylu and Britta Landfried and Bernd Arnold and Karl Heinz Plate and G{\"u}nter U. H{\"o}glinger and Holger Sueltmann and Peter Altevogt and Stefan Momma},
  booktitle={PLoS biology},
  year={2014}
}
Mechanisms behind how the immune system signals to the brain in response to systemic inflammation are not fully understood. Transgenic mice expressing Cre recombinase specifically in the hematopoietic lineage in a Cre reporter background display recombination and marker gene expression in Purkinje neurons. Here we show that reportergene expression in neurons is caused by intercellular transfer of functional Cre recombinase messenger RNA from immune cells into neurons in the absence of cell… CONTINUE READING

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