Extracellular Tat activates c-fos promoter in low serum-starved CD4+ T cells.

@article{Gibellini2001ExtracellularTA,
  title={Extracellular Tat activates c-fos promoter in low serum-starved CD4+ T cells.},
  author={Davide Gibellini and Maria Carla Re and Cristina Ponti and Claudio Celeghini and Elisabetta Melloni and Marco La Placa and Giorgio Zauli},
  journal={British journal of haematology},
  year={2001},
  volume={112 3},
  pages={663-70}
}
The regulatory human immunodeficiency virus-1 (HIV-1) Tat protein shows pleiotropic effects on the survival and growth of both HIV-1-infected and uninfected CD4+ T lymphocytes. In this study, we have demonstrated that low concentrations (10 ng/ml) of extracellular Tat protein induce the expression of both c-fos mRNA and protein in serum-starved Jurkat CD4… CONTINUE READING