Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia.

@article{LealLasarte2017ExtracellularTA,
  title={Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia.},
  author={Mar{\'i}a M Leal-Lasarte and Jaime Mu{\~n}oz Franco and Adahir Labrador-Garrido and David Patricio Viscarra del Pozo and Cintia Roodveldt},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2017},
  volume={31 7},
  pages={2797-2816}
}
Dysregulated microglial responses are central in neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar disease (FTLD). Pathologic TDP-43, which is typically found in intracellular inclusions, is a misfolding protein with emerging roles in ALS and FTLD. Recently, TDP-43 species have been found in extracellular fluids of patients; however, the overall implications of TDP-43-mediated signaling linked to neuroinflammation are poorly understood… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS
3 Citations
71 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 71 references

Similar Papers

Loading similar papers…