Extracellular Superoxide Dismutase in Cultured Astrocytes: Decrease in Cell-Surface Activity and Increase in Medium Activity by Lipopolysaccharide-Stimulation

@article{Iitsuka2012ExtracellularSD,
  title={Extracellular Superoxide Dismutase in Cultured Astrocytes: Decrease in Cell-Surface Activity and Increase in Medium Activity by Lipopolysaccharide-Stimulation},
  author={Ichiro Iitsuka and Akiko Motoyoshi-Yamashiro and Mitsuaki Moriyama and Yukiko Kannan-Hayashi and Yuka Fujimoto and Katsura Takano and Koji Murakami and Yukio Yoneda and Yoichi Nakamura},
  journal={Neurochemical Research},
  year={2012},
  volume={37},
  pages={2108-2116}
}
Under pathological conditions such as ischemia/reperfusion, a large amount of superoxide anion (O2 −) is produced and released in brain. Among three isozymes of superoxide dismutase (SOD), extracellular (EC)-SOD, known to be excreted outside cells and bound to extracellular matrix, should play a role to detoxify O2 − in extracellular space; however, a little is known about EC-SOD in brain. In order to evaluate the SOD activity in extracellular space of CNS as direct as possible, we attempted to… CONTINUE READING