Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase-Dependent SOCS-3 Gene Induction Requires c-Jun, Signal Transducer and Activator of Transcription 3, and Specificity Protein 3 Transcription Factors

@article{Wiejak2012ExtracellularSK,
  title={Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase-Dependent SOCS-3 Gene Induction Requires c-Jun, Signal Transducer and Activator of Transcription 3, and Specificity Protein 3 Transcription Factors},
  author={J. Wiejak and J. Dunlop and S. Gao and G. Borland and S. Yarwood},
  journal={Molecular Pharmacology},
  year={2012},
  volume={81},
  pages={657 - 668}
}
  • J. Wiejak, J. Dunlop, +2 authors S. Yarwood
  • Published 2012
  • Medicine, Biology
  • Molecular Pharmacology
  • SOCS-3 gene induction by cAMP-elevating agents or the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), in primary HUVECs was found to require PKCη- and PKCε-dependent extracellular signal-regulated kinase (ERK) activation. The minimal, ERK-responsive element of the SOCS-3 promoter was localized to a region spanning nucleotides −107 to the transcription start site and contains conserved binding sites for AP-1 and SP1/SP3 transcription factors, as well as proximal and… CONTINUE READING
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